Can Congress Regulate Firearms?: Printz v. United States and the Intersection of the Commerce Clause, the Tenth Amendment, and the Second Amendment

The recent U.S. Supreme Court decision in Printz v. United States restricted congressional legislative authority by striking down the interim provisions of the Brady Handgun Violence Prevention Act. The decision followed United States v. Lopez, in which the Court struck down the Gun-Free School Zones Act. In both cases, the Court restricted the congressional Commerce Power and renewed the strength of the Tenth Amendment in protecting states\u27 rights from federal intrusion. Because both cases involved statutes regulating firearms, however, they also raised important questions regarding the Second Amendment. Following the Lopez decision, some commentators argued that both the Tenth and Second Amendments restrict Congress\u27ability to regulate firearms. Now, after Printz, commentators are likely to argue again that the Court has placed a further significant restriction on federal firearms regulation. This Note argues that, while Printz raised important questions about the Commerce Power, the Tenth Amendment, and the Second Amendment, Congress\u27 authority to regulate firearms remains substantially intact. The Note demonstrates this by examining the Printz case in the context of the Court\u27s developing Tenth Amendment/Commerce Clause jurisprudence and its longstanding Second Amendment jurisprudence. The Note also proposes that the Supreme Court should reaffirm clearly its states\u27 rights interpretation of the Second Amendment to settle the debate over Congress\u27 authority to regulate firearms

Polly's Polyhedral Scheduling in the Presence of Reductions

The polyhedral model provides a powerful mathematical abstraction to enable effective optimization of loop nests with respect to a given optimization goal, e.g., exploiting parallelism. Unexploited reduction properties are a frequent reason for polyhedral optimizers to assume parallelism prohibiting dependences. To our knowledge, no polyhedral loop optimizer available in any production compiler provides support for reductions. In this paper, we show that leveraging the parallelism of reductions can lead to a significant performance increase. We give a precise, dependence based, definition of reductions and discuss ways to extend polyhedral optimization to exploit the associativity and commutativity of reduction computations. We have implemented a reduction-enabled scheduling approach in the Polly polyhedral optimizer and evaluate it on the standard Polybench 3.2 benchmark suite. We were able to detect and model all 52 arithmetic reductions and achieve speedups up to 2.21$\times$ on a quad core machine by exploiting the multidimensional reduction in the BiCG benchmark.Comment: Presented at the IMPACT15 worksho

Runtime-adaptive generalized task parallelism

Multi core systems are ubiquitous nowadays and their number is ever increasing. And while, limited by physical constraints, the computational power of the individual cores has been stagnating or even declining for years, a solution to effectively utilize the computational power that comes with the additional cores is yet to be found. Existing approaches to automatic parallelization are often highly specialized to exploit the parallelism of specific program patterns, and thus to parallelize a small subset of programs only. In addition, frequently used invasive runtime systems prohibit the combination of different approaches, which impedes the practicality of automatic parallelization. In the following thesis, we show that specializing to narrowly defined program patterns is not necessary to efficiently parallelize applications coming from different domains. We develop a generalizing approach to parallelization, which, driven by an underlying mathematical optimization problem, is able to make qualified parallelization decisions taking into account the involved runtime overhead. In combination with a specializing, adaptive runtime system the approach is able to match and even exceed the performance results achieved by specialized approaches.Mehrkernsysteme sind heutzutage allgegenwärtig und finden täglich weitere Verbreitung. Und während, limitiert durch die Grenzen des physikalisch Machbaren, die Rechenkraft der einzelnen Kerne bereits seit Jahren stagniert oder gar sinkt, existiert bis heute keine zufriedenstellende Lösung zur effektiven Ausnutzung der gebotenen Rechenkraft, die mit der steigenden Anzahl an Kernen einhergeht. Existierende Ansätze der automatischen Parallelisierung sind häufig hoch spezialisiert auf die Ausnutzung bestimmter Programm-Muster, und somit auf die Parallelisierung weniger Programmteile. Hinzu kommt, dass häufig verwendete invasive Laufzeitsysteme die Kombination mehrerer Parallelisierungs-Ansätze verhindern, was der Praxistauglichkeit und Reichweite automatischer Ansätze im Wege steht. In der Ihnen vorliegenden Arbeit zeigen wir, dass die Spezialisierung auf eng definierte Programmuster nicht notwendig ist, um Parallelität in Programmen verschiedener Domänen effizient auszunutzen. Wir entwickeln einen generalisierenden Ansatz der Parallelisierung, der, getrieben von einem mathematischen Optimierungsproblem, in der Lage ist, fundierte Parallelisierungsentscheidungen unter Berücksichtigung relevanter Kosten zu treffen. In Kombination mit einem spezialisierenden und adaptiven Laufzeitsystem ist der entwickelte Ansatz in der Lage, mit den Ergebnissen spezialisierter Ansätze mitzuhalten, oder diese gar zu übertreffen.Part of the work presented in this thesis was performed in the context of the SoftwareCluster project EMERGENT (http://www.software-cluster.org). It was funded by the German Federal Ministry of Education and Research (BMBF) under grant no. “01IC10S01”. Later work has been supported, also by the German Federal Ministry of Education and Research (BMBF), through funding for the Center for IT-Security, Privacy and Accountability (CISPA) under grant no. “16KIS0344”

Sambamba: A runtime system for online adaptive parallelization

Abstract. How can we exploit a microprocessor as efficiently as possible? The "classic" approach is static optimization at compile-time, optimizing a program for all possible uses. Further optimization can only be achieved by anticipating the actual usage profile: If we know, for instance, that two computations will be independent, we can run them in parallel. In the Sambamba project, we replace anticipation by adaptation. Our runtime system provides the infrastructure for implementing runtime adaptive and speculative transformations. We demonstrate our framework in the context of adaptive parallelization. We show the fully automatic parallelization of a small irregular C program in combination with our adaptive runtime system. The result is a parallel execution which adapts to the availability of idle system resources. In our example, this enables a 1.92 fold speedup on two cores while still preventing oversubscription of the system

Autonomous Materials Discovery Driven by Gaussian Process Regression with Inhomogeneous Measurement Noise and Anisotropic Kernels

A majority of experimental disciplines face the challenge of exploring large and high-dimensional parameter spaces in search of new scientific discoveries. Materials science is no exception; the wide variety of synthesis, processing, and environmental conditions that influence material properties gives rise to particularly vast parameter spaces. Recent advances have led to an increase in efficiency of materials discovery by increasingly automating the exploration processes. Methods for autonomous experimentation have become more sophisticated recently, allowing for multi-dimensional parameter spaces to be explored efficiently and with minimal human intervention, thereby liberating the scientists to focus on interpretations and big-picture decisions. Gaussian process regression (GPR) techniques have emerged as the method of choice for steering many classes of experiments. We have recently demonstrated the positive impact of GPR-driven decision-making algorithms on autonomously steering experiments at a synchrotron beamline. However, due to the complexity of the experiments, GPR often cannot be used in its most basic form, but rather has to be tuned to account for the special requirements of the experiments. Two requirements seem to be of particular importance, namely inhomogeneous measurement noise (input dependent or non-i.i.d.) and anisotropic kernel functions, which are the two concepts that we tackle in this paper. Our synthetic and experimental tests demonstrate the importance of both concepts for experiments in materials science and the benefits that result from including them in the autonomous decision-making process

Bioinformatics for Whole-Genome Shotgun Sequencing of Microbial Communities

The application of whole-genome shotgun sequencing to microbial communities represents a major development in metagenomics, the study of uncultured microbes via the tools of modern genomic analysis. In the past year, whole-genome shotgun sequencing projects of prokaryotic communities from an acid mine biofilm, the Sargasso Sea, Minnesota farm soil, three deep-sea whale falls, and deep-sea sediments have been reported, adding to previously published work on viral communities from marine and fecal samples. The interpretation of this new kind of data poses a wide variety of exciting and difficult bioinformatics problems. The aim of this review is to introduce the bioinformatics community to this emerging field by surveying existing techniques and promising new approaches for several of the most interesting of these computational problems

Characterisation of age and polarity at onset in bipolar disorder

Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.publishedVersio

CNS Recruitment of CD8+ T Lymphocytes Specific for a Peripheral Virus Infection Triggers Neuropathogenesis during Polymicrobial Challenge

Although viruses have been implicated in central nervous system (CNS) diseases of unknown etiology, including multiple sclerosis and amyotrophic lateral sclerosis, the reproducible identification of viral triggers in such diseases has been largely unsuccessful. Here, we explore the hypothesis that viruses need not replicate in the tissue in which they cause disease; specifically, that a peripheral infection might trigger CNS pathology. To test this idea, we utilized a transgenic mouse model in which we found that immune cells responding to a peripheral infection are recruited to the CNS, where they trigger neurological damage. In this model, mice are infected with both CNS-restricted measles virus (MV) and peripherally restricted lymphocytic choriomeningitis virus (LCMV). While infection with either virus alone resulted in no illness, infection with both viruses caused disease in all mice, with ∼50% dying following seizures. Co-infection resulted in a 12-fold increase in the number of CD8+ T cells in the brain as compared to MV infection alone. Tetramer analysis revealed that a substantial proportion (>35%) of these infiltrating CD8+ lymphocytes were LCMV-specific, despite no detectable LCMV in CNS tissues. Mechanistically, CNS disease was due to edema, induced in a CD8-dependent but perforin-independent manner, and brain herniation, similar to that observed in mice challenged intracerebrally with LCMV. These results indicate that T cell trafficking can be influenced by other ongoing immune challenges, and that CD8+ T cell recruitment to the brain can trigger CNS disease in the apparent absence of cognate antigen. By extrapolation, human CNS diseases of unknown etiology need not be associated with infection with any particular agent; rather, a condition that compromises and activates the blood-brain barrier and adjacent brain parenchyma can render the CNS susceptible to pathogen-independent immune attack

Characterisation of age and polarity at onset in bipolar disorder

Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe